Medicinal value of ginkgo in scientific research result

· Medicinal value of ginkgo in scientific research results

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· 1. Ginkgo biloba and hyperlipemia

· Ginkgo biloba leaves contain flavonoids, lactones, long chain phenols and other chemical components, the effective components of its preparations or extracts can correct hyperlipidemia microcirculation disorders, and can significantly reduce serum cholesterol, improve blood viscosity. The results showed that the contents of total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) in serum of rats in medium and high dose groups were significantly decreased, while the contents of high density lipoprotein cholesterol (HDL-C) were significantly increased, indicating that ginkgo biloba leaves can reduce blood lipid in hyperlipidemia rats. It shows that it can improve the "blood thickening" caused by lipoprotein metabolism and cholesterol intake, and has obvious effect on preventing hyperlipidemia. Source: Electronic Journal of General Stomatology Volume 6 / Issue 28, October 2019

· 2. Ginkgo and atherosclerosis

· In the treatment of atherosclerosis in type 2 diabetic rats, ginkgo biloba extract can greatly reduce the formation of new intima, and EGb200 and EGb10 groups are accompanied by increased proliferation and apoptosis of vascular smooth muscle cells. Improve the state of atherosclerosis. Effects of ginkgo biloba extract on atherosclerosis in type 2 diabetic rats [J].

· 3. Ginkgo and hypertension

· Ginkgo biloba extract can simultaneously reduce the adverse effects of blood cholesterol, triglyceride, very low density lipoprotein on the human body, reduce blood lipids, improve microcirculation, inhibit coagulation, thus promoting the treatment of hypertension significantly. Medicinal Value of Ginkgo biloba: Pharmacopoeia of the People's Republic of China, Chemical Industry Press, 2005 edition 1, P281

4. Ginkgo and diabetes

Ginkgo biloba leaf extract (GBE) is an active substance extracted from ginkgo biloba leaves by scientists in academic research circles. The main active components are ginkgo biloba flavonoids and ginkgo biloba lactones. By establishing a rat model of diabetic cardiomyopathy and intraperitoneal injection of GBE at a certain dose, it was found that GBE intervention could significantly reduce the glycemic index and increase the blood insulin level of diabetic rats. It was found that GBE can reduce blood glucose and improve insulin resistance in type 2 diabetic rats by intragastric administration of different doses of GBE. Chinese Journal of Integrated Traditional and Western Medicine Nephropathy, Vol 20, No 4, April 2019 Progress in the treatment of diabetic nephropathy with ginkgo biloba extract. Diabetic nephropathy

5, Ginkgo and cerebral vasospasm

· The characteristics of ginkgo biloba leaf extract on blood vessels are that it can eliminate vasospasm and restore the normal circulation function in the area of vascular paralysis, maintain the difference of tension between arteries, and facilitate the timely removal of metabolites in the vein. Ginkgolide reduced the vasospasm caused by thromboxane analogues by 90% in 15 minutes. Proceedings of international Symposium on Ginkgo biloba -- cerebral vasospasm

6. Ginkgo biloba and acute cerebral infarction in the elderly Flavonoids,

· lactones and other active substances in ginkgo biloba leaf extract, these active substances can effectively remove free radicals, increase blood flow in the brain, prevent oxidation, improve brain metabolism, to protect the brain has a certain effect.

7. Ginkgo biloba and ischemic stroke Ischemic stroke

· (IS) IS the result of multi-factor, multi-mechanism and multi-link malignant cascade process, in which blood pressure, blood lipid and blood glucose are closely related. Through the experiment

· 8. Ginkgo biloba and hemorheology

· By pharmacological activity research shows that the main composition of ginkgo biloba injection is bitter lactones ginkgo flavone glycosides and ginkgo biloba, the ginkgo flavone glycosides can prevent oxidation and scavenging free radicals, also has the change of hemodynamic, thus increase red blood cell deformation ability, reduce the blood viscosity, promote brain blood circulation, accelerate the metabolism of brain cells, to alleviate the effect of high blood coagulation state. Clinical efficacy of injection in patients with acute cerebral infarction and the influence of oxidative stress and NIHSS score [J]. Shaanxi traditional Chinese medicine, 2017,38 (1) : 16-17.

· 9. Ginkgo and thrombosis

· Ginkgolide can antagonize platelet aggregation caused by platelet activating factor, effectively reduce platelet activity and prevent the occurrence of thrombosis. Urinary kinkinase and pancreatic kinkinase in patients with precirculation non-progressive cerebral infarction [J]. Journal of jiangsu university: medical edition, 2017,27 (2) : 176-178.

· 10. Ginkgo biloba and antibacterial

· activity Studies have shown that flavonoids of ginkgo biloba has good bacteriostasis, and antibacterial mechanism of flavonoids, belong to the polyphenol compounds, pH value bias acid, can let the fungus protein degeneration occurs, or destroy the integrity of the cell membrane, so that the microorganism to produce functional disorder, which performs the function of bacteriostasis. Study on antibacterial activity of extracts from Ginkgo biloba leaves

· 11. Ginkgo and Parkinson's disease (PD)

· Ginkgo biloba extract can significantly increase the content of dopamine neurotransmitter in the brain of PD rats, and improve the symptoms of dyskinesia in PD rats. At the same time, ginkgo biloba extract can effectively inhibit the above inflammatory response, thereby reducing the dopamine in the substantia nigra of rats